Cyclin-dependent kinase 7 (IPR037770)

Short name: CDK7

Overlapping homologous superfamilies

Family relationships



Cyclin-dependent kinase 7 (CDK7) is a serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. It is activated by binding to a cyclin; binding to a different cyclin and phosphylation of another kinase progresses the cell cycle. CDK7 binds cyclin-B and phosphorylates CDK1 during G2-M transition, and phosphorylates CDK2 and binds to cyclins during G1-S transition [PMID: 17386261,PMID: 11113184]. CDK7 phosphorylates and activates p53 following DNA damage [PMID: 9372954], but CDK7 is then inactivated by p53, which arrests the cell cycle, allowing the cell to recover or undergo apoptosis [PMID: 9840937]. CDK7 is also the catalytic subunit of the CDK-activating kinase (CAK) complex, which also contains cyclin-H (CCNH) and MAT1 [PMID: 16327805,PMID: 10024882]. In turn, the CAK associates with the core-TFIIH to form the TFIIH basal transcription factor [PMID: 9852112].

This entry includes CDK7 from animals, Kin28 from budding yeasts and Crk1 (also known as Mcs6) from fission yeasts. S. pombe possesses two CAKs, the nonessential Csk1 and the essential Mcs6 kinases, corresponding to the yeast Cak1 and the metazoan CDK7, respectively. Mcs6 modulates gene expression through both its CAK and CTD kinase activities [PMID: 25691663]. Kin28 is the closest homologue of CDK7 from budding yeasts. It forms a complex with Ccl1 and Tfb3. This complex associate with TFIIH for transcription regulating activity, but does not display CAK activity [PMID: 27759017]. Instead, Cak1, a single-subunit kinase distantly related to Cdk, catalyzes Cdk activation at both transitions of the budding yeast cell cycle [PMID: 8752210].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity

Cellular Component

GO:0005675 transcription factor TFIIH holo complex
GO:0070985 transcription factor TFIIK complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.