Pathways & interactions
Dok1/2/3, PTB domain (IPR037751)
Short name: Dok1/2/3_PTB
Overlapping homologous superfamilies
- IRS-type PTB domain (IPR002404)
- Dok1/2/3, PTB domain (IPR037751)
The Dok family adapters are phosphorylated by different protein tyrosine kinases. Dok proteins are involved in processes such as modulation of cell differentiation and proliferation, as well as in control of the cell spreading and migration The Dok protein contains an N-terminal pleckstrin homology (PH) domain followed by a central phosphotyrosine binding (PTB) domain, which has a PH-like fold, and a proline- and tyrosine-rich C-terminal tail. The PH domain binds to acidic phospholids and localizes proteins to the plasma membrane, while the PTB domain mediates protein-protein interactions by binding to phosphotyrosine-containing motifs [PMID: 19909370].
There are 7 mammalian Dok member (Dok-1 to 7). Dok-1 and Dok-2 act as negative regulators of the Ras-Erk pathway downstream of many immunoreceptor-mediated signaling systems, and it is believed that recruitment of p120 rasGAP by Dok-1 and Dok-2 is critical to their negative regulation [PMID: 19909370]. Dok-3 is a negative regulator of the activation of JNK and mobilization of Ca2+ in B-cell receptor-mediated signaling, interacting with SHIP-1 and Grb2 [PMID: 16436051].
This entry represents the PTB domain of Dok1/2/3.
- cd01203 (PTB_DOK1_DOK2_DOK3)