Domain

Rhodopsin kinase, catalytic domain (IPR037716)

Short name: GRK1_dom

Overlapping homologous superfamilies

Domain relationships

Description

Rhodopsin kinase (also known as G-protein-coupled Receptor Kinase 1, GRK1) is a retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade [PMID: 1730692]. Together with recoverin (a Ca2+-binding protein), GRK1 regulates cone phototransduction during photoreceptor light adaptation [PMID: 25667411, PMID: 25673692].

This entry represents the catalytic domain of GRK1.

GO terms

Biological Process

GO:0022400 regulation of rhodopsin mediated signaling pathway
GO:0007601 visual perception

Molecular Function

GO:0050254 rhodopsin kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD