MSK2, N-terminal catalytic domain (IPR037714)

Short name: MSK2_N_dom

Overlapping homologous superfamilies

Domain relationships



MSK1/2 (Mitogen and Stress-induced Kinase, also known as RSKB) are partially redundant serine/threonine kinases that are phosphorylated downstream of MAPK (Erk and/or p38-mediated) and cAMP signal transduction pathways [PMID: 27973548]. They phosphorylate multiple substrates, including CREB and Histone H3 and regulate specific subsets of Immediate Early genes (IEG) [PMID: 27376065]. They are involved in limiting inflammation in innate immunity and is implicated in neurodegeneration and synaptic plasticity [PMID: 27376065]. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family, similar to 90 kDa ribosomal protein S6 kinases (RSKs) [PMID: 15289607].

This entry represents the N-terminal catalytic domain of MSK2. MSK2 is also known as ribosomal protein S6 kinase alpha-4 (RPS6KA4).

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.