Domain

Microtubule-associated serine/threonine-protein kinase, catalytic domain (IPR037711)

Short name: MAST

Overlapping homologous superfamilies

Domain relationships

  • Protein kinase domain (IPR000719)
    • Microtubule-associated serine/threonine-protein kinase, catalytic domain (IPR037711)

Description

MAST (Microtubule-Associated Serine/Threonine) kinases are characterised by containing a serine/threonine kinase domain and a PDZ (postsynaptic density protein-95/discs large/zona occludens-1) domain [PMID: 18206861]. There are four mammalian MAST kinases, named MAST1-MAST4. MAST1, MAST2, and MAST3 bind and phosphorylate the tumor suppressor PTEN, and may contribute to the regulation and stabilization of PTEN [PMID: 15951562]. MAST1 links the dystrophin/utrophin network with microtubule filaments via the syntrophins [PMID: 10404183]. MAST1 localises in the DAPC/UAPC, which is found within the postsynaptic region of the neuromuscular junction (NMJ) and central synapses [PMID: 18206861]. The splice variant of its C-terminal affects its subcellular localisation within neurons [PMID: 12614677]. MAST2 is involved in the regulation of the Fc-gamma receptor of the innate immune response in macrophages, and may also be involved in the regulation of the Na+/H+ exchanger NHE3 [PMID: 16159897].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD