Domain

DNA-dependent protein kinase catalytic subunit, catalytic domain (IPR037706)

Short name: DNA-PK_dom

Overlapping homologous superfamilies

Domain relationships

Description

This entry represents the catalytic domain of DNA-dependent protein kinase catalytic subunit (DNA-PKcs). The DNA-PK complex is composed of DNA-PKcs, the heterodimer Ku70/80, XRCC4, and ligase IV. The DNA-PK complex is involved in non-homologous end joining (NHEJ), a process of repairing double strand breaks (DSBs) by joining together two free DNA ends of little homology [PMID: 14734805].

GO terms

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0004677 DNA-dependent protein kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD