PI3K-C2-alpha, catalytic domain (IPR037705)

Short name: PI3K-C2-alpha_dom

Overlapping homologous superfamilies

Domain relationships


This entry represents the catalytic domain of PI3K-C2-alpha, which is a Class II phosphoinositide-3-kinase (PI3K) that generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). It plays key roles in clathrin assembly and clathrin-mediated membrane trafficking [PMID: 17110375], insulin signaling [PMID: 17644513], and vascular smooth muscle contraction [PMID: 17179444].

PI3Ks can be divided into three main classes (I, II, and III), defined by their substrate specificity, regulation, and domain structure. Class I PI3Ks are the only enzymes capable of converting PtdIns(4,5)P2 to the critical second messenger PtdIns(3,4,5)P3. Class II PI3Ks preferentially use PtdIns as a substrate to produce PtdIns(3)P, but can also phosphorylate PtdIns(4)P. They function as monomers and do not associate with any regulatory subunits. Class II enzymes contain an N-terminal Ras binding domain, a lipid binding C2 domain, a PI3K homology domain of unknown function, an ATP-binding cataytic domain, a Phox homology (PX) domain, and a second C2 domain at the C terminus [PMID: 9255069, PMID: 10579926].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0035004 phosphatidylinositol 3-kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.