Serine/threonine-protein kinase greatwall, catalytic domain (IPR037638)

Short name: MASTL_STKc

Overlapping homologous superfamilies

Domain relationships

  • Protein kinase domain (IPR000719)
    • Serine/threonine-protein kinase greatwall, catalytic domain (IPR037638)


The MASTL kinases carry only a catalytic domain, which contains a long insertion relative to MAST kinases. MASTL, also called greatwall kinase (Gwl), is involved in the regulation of mitotic entry, which is controlled by the coordinated activities of protein kinases and opposing protein phosphatases (PPs) [PMID: 20818157]. The cyclin B/CDK1 complex induces entry into M-phase while PP2A-B55 shows anti-mitotic activity. MASTL/Gwl is activated downstream of cyclin B/CDK1 and indirectly inhibits PP2A-B55 by phosphorylating the small protein alpha-endosulfine (Ensa) or the cAMP-regulated phosphoprotein 19 (Arpp19), resulting in M-phase progression [PMID: 22754657]. Gwl kinase may also play roles in mRNA stabilization and DNA checkpoint recovery [PMID: 22469975, PMID: 21708943]. The human MASTL gene has also been named FLJ14813; a missense mutation in FLJ14813 is associated with autosomal dominant thrombocytopenia [PMID: 19460416].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.