Domain

Diacylglycerol kinase delta, SAM domain (IPR037606)

Short name: DGK-delta_SAM

Overlapping homologous superfamilies

Domain relationships

Description

DGK-delta is a member of the diacylglycerol kinase family. DGK-delta is involved in the regulation of clathrin-dependent endocytosis [PMID: 17880279]. The SAM domain of DGK-delta proteins can form high molecular weight homooligomers through head-to-tail interactions as well as heterooligomers with the SAM domain of DGK-eta proteins. The oligomerization plays a role in the regulation of the DGK-delta intracellular localization: it inhibits the translocation of the protein to the plasma membrane from the cytoplasm [PMID: 18334213]. The SAM domain also can bind Zn at multiple (not conserved) sites driving the formation of highly ordered large sheets of polymers, thus suggesting that Zn may play important role in the function of DCK-delta [PMID: 20857926].

This entry represents the SAM domain of DGK-delta.

GO terms

Biological Process

GO:0007165 signal transduction

Molecular Function

GO:0004143 diacylglycerol kinase activity
GO:0046982 protein heterodimerization activity
GO:0042803 protein homodimerization activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD