Fibrinogen gamma chain (IPR037581)

Short name: Fibrinogen_gamma

Overlapping homologous superfamilies

Family relationships



Fibrinogens are cleaved by thrombin to yield fibrins, which polymerize to form the insoluble fibrin clot which blocks sites of vascular injury, preventing further blood loss. The clot is subsequently degraded by plasmin (fibrinolysis) [PMID: 155369]. There are three fibrinogens, alpha, beta and gamma [PMID: 7649481]. Thrombin activates fibrinogen to release a fibrinopeptide [PMID: 2404012]. The newly exposed N terminus forms an Glu-Lys isopeptide bond, which is stabilized by factor XIIIA [PMID: 2143188]. Fibrinogen is also required for successful pregnancy, and in knockout mice fatal uterine bleeding occurs around the tenth day of gestation [PMID: 7649481].

This entry represents the gamma chain of fibrinogen (FGG). Although a component of the fibrin clot, FGG is not a requirement for clot formation. FGG is not cleaved by thrombin, and no fibrinopeptide is released [PMID: 12871494]. FGG carries the main binding site for the platelet receptor [PMID: 10631982].

GO terms

Biological Process

GO:0007596 blood coagulation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.