Thioredoxin-related transmembrane protein 2, thioredoxin domain (IPR037463)

Short name: TMX2_thioredoxin_dom

Overlapping homologous superfamilies

Domain relationships


This entry represents the thioredoxin (TRX) domain found in thioredoxin-related transmembrane protein 2 (TMX2). In TMX2, the TRX domain redox active CXXC motif is replaced with SXXC. In addition to the TRX domain, TMX2 may contain an N-terminal signal peptide, a potential transmembrane domain, an Myb DNA-binding domain repeat signature, an endoplasmic reticulum (ER) membrane retention signal (KKXX-like motif), and a dileucine motif in the tail [PMID: 12670024, PMID: 15643448].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.