PACSIN2, F-BAR domain (IPR037453)
Short name: PACSIN2_F-BAR
Overlapping homologous superfamilies
- AH/BAR domain superfamily (IPR027267)
- F-BAR domain (IPR031160)
- PACSIN2, F-BAR domain (IPR037453)
PACSIN2 (protein kinase C and casein kinase substrate in neurons protein 2, also known as Syndapin-2) belongs to the PACSIN family that contains a N-terminal F-BAR (FCH-BAR) domain and a C-terminal SH3 domain [PMID: 23236520]. They are cytoplasmic phosphoproteins that play a role in vesicle formation and transport [PMID: 11179684].
PACSIN2 interacts with several proteins such as Rac1, dynamin, Neuronal Wiskott-Aldrich Syndrome Protein (N-WASP), and synaptojanin via its C-terminal Src homology 3 (SH3) domain [PMID: 23129763]. PACSIN2 negatively regulates the EGF (epidermal growth factor) receptor activation and signaling [PMID: 23129763, PMID: 21693584]. It plays an important role in caveolae membrane sculpting [PMID: 21610094].
This entry represents the F-BAR domain of PACSIN2. F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization [PMID: 19549836].
- cd07679 (F-BAR_PACSIN2)