Sorting nexin-14, PX domain (IPR037436)

Short name: SNX14_PX

Overlapping homologous superfamilies

Domain relationships


SNX14 (sorting nexin-14) is expressed in the embryonic nervous system of mammals such as mice, being co-expressed with homoprotein islet-1 in several tissues [PMID: 11500980]. SNX14 levels increase progressively during neuronal development and its knockdown impairs both excitatory and inhibitory synaptic transmission, suggesting a role in neuronal development and function [PMID: 24859318]. SNX14 contains an N-terminal PXA domain, a regulator of G protein signaling (RGS) domain, a PX domain, and a C-terminal PXC domain [PMID: 25148684]. Its RGS domain is non-functional as a GTPase activator for Galpha, but it binds to and sequesters Galpha, thus inhibiting downstream cAMP production [PMID: 25795301].

This entry represents the PX domain of SNX14. The PX domain is a phosphoinositide (PI) binding module present in many proteins with diverse functions [PMID: 11684018, PMID: 16782399].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.