Exonuclease Mut-7, DEDDy 3'-5' exonuclease domain (IPR037432)

Short name: Mut-7_DEDDy_dom

Overlapping homologous superfamilies

Domain relationships


This entry represents the DEDDy domain found in Caenorhabditis elegans mut-7 and similar proteins found in metazoans. Mut-7 is implicated in posttranscriptional gene silencing [PMID: 10535732]. It contains a DEDDy-type DnaQ-like 3'-5' exonuclease domain possessing three conserved sequence motifs, termed ExoI, ExoII and ExoIII, with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis [PMID: 11222749].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008408 3'-5' exonuclease activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.