RNA exonuclease 4, DEDDh 3'-5' exonuclease domain (IPR037431)

Short name: REX4_DEDDh_dom

Overlapping homologous superfamilies

Domain relationships


This entry represent the DEDDh 3'-5' exonuclease domain found in RNA exonuclease 4 (REX4 or Rex4p) [PMID: 15525710]. It is a DEDDh-type DnaQ-like 3'-5' exonuclease containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis [PMID: 15451662]. REX proteins function in the processing and maturation of many RNA species, similar to the function of Escherchia coli RNase T [PMID: 17293595].

GO terms

Biological Process

GO:0006364 rRNA processing

Molecular Function

GO:0008408 3'-5' exonuclease activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.