Domain

Sorting nexin-4, BAR domain (IPR037430)

Short name: SNX4_BAR

Overlapping homologous superfamilies

Domain relationships

None.

Description

SNX4 is involved in recycling traffic from the sorting endosome (post-Golgi endosome) back to the late Golgi. It shows a similar domain architecture as SNX1-2, among others, containing a Bin/Amphiphysin/Rvs (BAR) domain, which detects membrane curvature, C-terminal to the PX domain [PMID: 17994011]. SNX4 is implicated in the regulation of plasma membrane receptor trafficking and interacts with receptors for EGF, insulin, platelet-derived growth factor and the long form of the leptin receptor [PMID: 9819414].

This entry represents the BAR domain of SNX4 from Metazoa. BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions [PMID: 19379681].

GO terms

Biological Process

GO:0015031 protein transport

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD