Rvs161/Hob3, BAR domain (IPR037429)

Short name: Rvs161/Hob3_BAR

Overlapping homologous superfamilies

Domain relationships

  • BAR domain (IPR004148)
    • Rvs161/Hob3, BAR domain (IPR037429)


BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions [PMID: 19379681]. This entry represents the BAR domain found in fungal proteins with similarity to Saccharomyces cerevisiae Reduced viability upon starvation protein 161 (Rvs161p) and Schizosaccharomyces pombe Hob3 (homologue of Bin3). S. cerevisiae Rvs161p plays a role in regulating cell polarity, actin cytoskeleton polarization, vesicle trafficking, endocytosis, bud formation, and the mating response. It forms a heterodimer with another BAR domain protein Rvs167p. Rvs161p and Rvs167p share common functions but are not interchangeable [PMID: 11481676, PMID: 16394103]. Their BAR domains cannot be replaced with each other and the overexpression of one cannot suppress the mutant phenotypes of the other. S. pombe Hob3 is important in regulating filamentous actin localization and may be required in activating Cdc42 and recruiting it to cell division sites [PMID: 11274158]. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions [PMID: 15043839].

GO terms

Biological Process

GO:0007015 actin filament organization

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.