Domain

Sorting nexin-9, PX domain (IPR037426)

Short name: SNX9_PX

Overlapping homologous superfamilies

Domain relationships

Description

Sorting nexin 9 (SNX9) has been suggested to be involved in the endocytic process as an accessory factor [PMID: 11879186]. SNX9 has binding sites for both clathrin and adaptor protein AP-2 in a low complexity region, and binds dynamin-2 (Dyn2) by its SH3 domain. SNX9 has its own membrane-binding activity, mediated by a carboxyl-terminal region containing the PX domain and the BAR domain [PMID: 12952949]. Endogenous SNX9 partially co-localizes with AP-2 and Dyn2 at the plasma membrane, and over expression in K562 and HeLa cells of truncated versions of SNX9 inhibits the uptake of transferrin [PMID: 12952949]. Moreover, SNX9 is required for efficient clathrin-mediated endocytosis, which suggests that it functions to regulate dynamin activity [PMID: 15703209].

SNXs are Phox homology (PX) domain containing proteins that are involved in regulating membrane traffic and protein sorting in the endosomal system. SNX9 also contains a BAR and a SH3 domain. This entry represents the PX domain of sorting nexin-9. The PX domain is a phosphoinositide (PI) binding module present in many proteins with diverse functions [PMID: 11439176].

GO terms

Biological Process

GO:0006897 endocytosis
GO:0006886 intracellular protein transport
GO:0000281 mitotic cytokinesis

Molecular Function

GO:0035091 phosphatidylinositol binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD