YfmP, Helix-Turn-Helix DNA binding domain (IPR037392)

Short name: YfmP_HTH

Overlapping homologous superfamilies

Domain relationships


This entry represents the N-terminal HTH (helix-turn-helix) domain of YfmP and related proteins. YfmP is a a transcription regulator that regulates the multidrug efflux protein, YfmO, and indirectly regulates the expression of the Bacillus subtilis copZA operon encoding a metallochaperone, CopZ, and a CPx-type ATPase efflux protein, CopA [PMID: 14663075]. These proteins belong to the MerR superfamily of transcription regulators that promote expression of several stress regulon genes by reconfiguring the spacer between the -35 and -10 promoter elements. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules [PMID: 12829265].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.