Tyrosine-protein kinase BAZ1B, bromodomain (IPR037375)

Short name: BAZ1B_Bromo

Overlapping homologous superfamilies

Domain relationships

  • Bromodomain (IPR001487)
    • Tyrosine-protein kinase BAZ1B, bromodomain (IPR037375)


BAZ1B (also known as Williams-Beuren syndrome transcription factor, WSTF) is a component of the WICH complex (WSTF-ISWI ATP-dependent chromatin-remodelling complex). It has intrinsic tyrosine kinase activity by means of a domain that shares no sequence homology to any known kinase fold. It has been shown to phosphorylate Tyr 142 of H2A [PMID: 19092802]. It is involved in chromatin assembly, RNA polymerase I and III gene regulation, vitamin D metabolism, and DNA repair [PMID: 21326359].

GO terms

Biological Process

GO:0006338 chromatin remodeling

Molecular Function

GO:0004713 protein tyrosine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.