PREX2, DEP domain 1 (IPR037367)

Short name: Rex2_DEP_1

Overlapping homologous superfamilies

Domain relationships

  • DEP domain (IPR000591)
    • PREX2, DEP domain 1 (IPR037367)


PREX2 functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein [PMID: 15304343]. It contains an N-terminal RhoGEF domain, two DEP and PDZ domains.

This entry represents the first DEP domain of PREX2.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0030676 Rac guanyl-nucleotide exchange factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.