BOULE/DAZ family (IPR037366)

Short name: BOULE/DAZ

Overlapping homologous superfamilies


Family relationships


In humans, the DAZ gene family consists of DAZ on the Y chromosome and 2 autosomal members: DAZL (DAZ-like) and BOULE. Although the DAZ gene evolved relatively recently and is present only in primates, DAZL and BOULE are much more ancient and conserved. BOULE homologues are present throughout eumetazoan animals, from sea anemones to mammals, and DAZL homologues are present in bony fish, amphibians, reptiles, birds, and mammals [PMID: 20657660]. BOULE is highly expressed in the testis, whereas DAZL appears to be highly expressed in both the testis and the ovary [PMID: 22523742].

DAZ family members are RNA binding proteins that play important roles in animal germ cell development [PMID: 27358391, PMID: 26327816]. They function as adaptors for target mRNA transport and activators of their translation. Deletion of the DAZ gene is the most common cause of infertility in humans [PMID: 26327816].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003729 mRNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.