Sec13/Seh1 family (IPR037363)

Short name: Sec13/Seh1_fam

Overlapping homologous superfamilies

Family relationships


Seh1 and Sec13 are WD40 repeat containing proteins. They are subunits of the Nup84 (Nup107-160 complex in higher eukaryotes) nuclear pore subcomplex [PMID: 10747086] and the the SEA complex (GATOR1 complex in higher eukaryotes) [PMID: 21454883, PMID: 27672113, PMID: 25934700].

The Nup107-160 complex, which is the major structural subcomplex of the nuclear pore complex (NPC), functions in the regulation of mRNA export as well as in the assembly and distribution of NPCs within the nuclear envelope, and may also have functions independent of nucleocytoplasmic transport [PMID: 21521741].

In budding yeasts, the SEA complex associates with the vacuole and is involved in intracellular trafficking, amino acid biogenesis, and response to nitrogen starvation [PMID: 21454883]. In Drosophila, GATOR1 complex inhibits TORC1 activity in response to amino acid limitation and contributes to multiple aspects of the development [PMID: 27672113].

Besides Nup84 and SEA complexes, Sec13 is also part of the COPII vesicle coat required for ER-to-Golgi transport [PMID: 17604721, PMID: 14517296].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005198 structural molecule activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.