Heparan sulfate sulfotransferase (IPR037359)

Short name: NST/OST

Overlapping homologous superfamilies

Family relationships



Seven 3-O-sulfotransferase isoforms in the human genome are involved in the biosynthesis of 3-O-sulfated heparan sulfate [PMID: 17131147]. These enzymes catalyze the transfer of a sulfo group from the sulfo donor, 3'-phosphoadenosine-5'-phosphosulfate (PAPS), to the 3-OH position of a glucosamine unit of heparin sulfate (HS). 3-O-sulfation is critically important for anticoagulant activity [PMID: 6935668]. The key control of anticoagulant HS synthesis is regulation of the expression of 3-O-sulfotransferase isoforms 1 and 5 (3-OST-1 and 3-OST-5). 3-O-sulfation is also involved in the regulation of neural development [PMID: 26731579, PMID: 15452147, PMID: 23451335].

3-OST proteins exhibit similarity with the heparan biosynthetic enzyme NST (bifunctional HS N-deacetylase/N-sulfotransferase). It appears that a common sulfotransferase structure is shared by these two types of heparan biosynthetic enzyme [PMID: 9346953]. The bifunctional enzyme catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in HS [PMID: 10758005].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008146 sulfotransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.