Histone methyltransferase complex subunit ASH2 (IPR037353)

Short name: ASH2

Overlapping homologous superfamilies

Family relationships



The trithorax-group (trxG) protein Ash2 from C. elegans (or ASH2L in mammals) is a component of the Set1/Ash2 histone methyltransferase (HMT) complex that methylates 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation [PMID: 12670868, PMID: 21527717]. Mammals posses several SET1 family proteins (MLL1-4, SET1A, and SET1B). ASH2L is a core component of all the resulting mammalian histone H3K4 methyltransferase complexes, including mixed lineage leukemia (MLL) complexes [PMID: 28160335].

S. cerevisiae Bre2 is homologous to Ash2 [PMID: 11742990]. TRAUCO (TRO) is the homologue from Arabidopsis, which is required for early embryogenesis [PMID: 20118203].

GO terms

Biological Process

GO:0051568 histone H3-K4 methylation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0048188 Set1C/COMPASS complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.