Pathways & interactions
SOCS7, SOCS box domain (IPR037346)
Short name: SOCS7_SOCS
Overlapping homologous superfamilies
- SOCS box domain (IPR001496)
- SOCS7, SOCS box domain (IPR037346)
This entry represents the SOCS box domain of SOCS7.
SOCS7 is a member of the suppressor of cytokine signaling family of proteins. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation [PMID: 16127460]. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA [PMID: 15677474].
The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions [PMID: 9869640, PMID: 16675548].
- cd03741 (SOCS_SOCS7)