SOCS7, SOCS box domain (IPR037346)

Short name: SOCS7_SOCS

Overlapping homologous superfamilies

Domain relationships


This entry represents the SOCS box domain of SOCS7.

SOCS7 is a member of the suppressor of cytokine signaling family of proteins. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation [PMID: 16127460]. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA [PMID: 15677474].

The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions [PMID: 9869640, PMID: 16675548].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.