SOCS6, SOCS box domain (IPR037345)
Short name: SOCS6_SOCS
Overlapping homologous superfamilies
- SOCS box domain (IPR001496)
- SOCS6, SOCS box domain (IPR037345)
This entry represents the SOCS box domain of SOCS6.
Suppressor of cytokine signaling (SOCS) family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. However, SOCS6 does not interact with cytokine signaling intermediate molecules or inhibit cytokine receptor signaling. SOCS6 can interact with c-KIT, a receptor tyrosine kinase that mediates the cellular response to stem cell factor (SCF). SOCS6 has ubiquitin ligase activity toward c-KIT and regulates c-KIT protein turnover in cells, suppressing c-KIT-dependent pathways [PMID: 21030588]. SOCS6 negatively regulates receptor tyrosine kinase Flt3 activation, the downstream Erk signaling pathway, and cell proliferation [PMID: 22952242].
The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions [PMID: 9869640, PMID: 16675548].
- cd03740 (SOCS_SOCS6)