SOCS4, SOCS box domain (IPR037342)

Short name: SOCS4_SOCS

Overlapping homologous superfamilies

Domain relationships


This entry represents the SOCS box domain of SOCS4.

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS4 (Suppressor of cytokine signalling 4) is the substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins [PMID: 17997974]. SOCS4 and SOCS5 regulate epidermal growth factor receptor signaling [PMID: 15590694].

The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions [PMID: 9869640, PMID: 16675548].

GO terms

Biological Process

GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.