Domain

Cytidine monophosphate-N-acetylneuraminic acid hydroxylase, Rieske domain (IPR037339)

Short name: CMP-Neu5Ac_hydroxylase_Rieske

Overlapping homologous superfamilies

Domain relationships

Description

This entry represents the N-terminal Rieske domain of cytidine monophosphate-N-acetylneuraminic acid (CMP Neu5Ac). The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer [PMID: 11460929]. CMP Neu5Ac hydroxylase is the key enzyme for the synthesis of N-glycolylneuraminic acid (NeuGc) from N-acetylneuraminic acid (Neu5Ac), NeuGc and Neu5Ac are members of a family of cell surface sugars called sialic acids [PMID: 7608218, PMID: 8132639, PMID: 12524037]. All mammals except humans have both NeuGc variants on their cell surfaces. In humans, the gene encoding CMP Neu5Ac hydroxylase has a mutation within its coding region that abolishes NeuGc production [PMID: 9675135, PMID: 9624188].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
  • cd03473 (Rieske_CMP_Neu5Ac_hydrolase_N)