Domain

Ankyrin repeat and SOCS box protein 1, SOCS box domain (IPR037331)

Short name: ASB1_SOCS

Domain relationships

  • SOCS box domain (IPR001496)
    • Ankyrin repeat and SOCS box protein 1, SOCS box domain (IPR037331)

Description

ASB (ankyrin SOCS box) family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence [PMID: 9419338]. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system [PMID: 16325183]. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2 [PMID: 16675548]. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.

This entry represents the SOCS box domain of ASB1.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD