EDEM3, PA domain (IPR037322)

Short name: EDEM3_PA

Overlapping homologous superfamilies


Domain relationships

  • PA domain (IPR003137)
    • EDEM3, PA domain (IPR037322)


EDEM3 is involved in endoplasmic reticulum-associated degradation (ERAD). It accelerates the glycoprotein degradation by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans [PMID: 25092655].

This entry represents the PA (protease associated) domain of EDEM3. The function of this domain is not clear.

GO terms

Biological Process

GO:1904382 mannose trimming involved in glycoprotein ERAD pathway

Molecular Function

GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.