TNF receptor-associated factor 5, MATH domain (IPR037308)

Short name: TRAF5_MATH

Overlapping homologous superfamilies


Domain relationships

  • MATH/TRAF domain (IPR002083)
    • TNF receptor-associated factor 5, MATH domain (IPR037308)


TNF receptor-associated factor 5 (TRAF5) is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. TRAF5 mediates activation of NF-kappa-B and probably JNK [PMID: 8663299, PMID: 8790348, PMID: 10449775, PMID: 17633015]. TRAF5 contains a RING finger domain, five zinc finger domains, and a TRAF domain.

The TRAF domain can be divided into a more divergent N-terminal alpha helical region (TRAF-N), and a highly conserved C-terminal MATH subdomain (TRAF-C) with an eight-stranded beta-sandwich structure. TRAF-N mediates trimerization while TRAF-C interacts with receptors [PMID: 10206649, PMID: 10518213].

GO terms

Biological Process

GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling

Molecular Function

GO:0005164 tumor necrosis factor receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.