TNF receptor-associated factor 4, MATH domain (IPR037307)

Short name: TRAF4_MATH

Overlapping homologous superfamilies


Domain relationships

  • MATH/TRAF domain (IPR002083)
    • TNF receptor-associated factor 4, MATH domain (IPR037307)


TNF receptor-associated factor 4 (TRAF4) is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. TRAF4 plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. It regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. TRAF4 modulates TRAF6 functions [PMID: 12023963, PMID: 12801526, PMID: 16052631, PMID: 16157600, PMID: 18953416, PMID: 19937093]. In mouse, it has been shown to be required for normal skeleton development, and for normal development of the respiratory tract [PMID: 10934170]. TRAF4 contains a RING finger domain, seven zinc finger domains, and a TRAF domain.

The TRAF domain can be divided into a more divergent N-terminal alpha helical region (TRAF-N), and a highly conserved C-terminal MATH subdomain (TRAF-C) with an eight-stranded beta-sandwich structure. TRAF-N mediates trimerization while TRAF-C interacts with receptors [PMID: 10206649, PMID: 10518213].

GO terms

Biological Process

GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0046330 positive regulation of JNK cascade

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.