Pathways & interactions
TNF receptor-associated factor 4, MATH domain (IPR037307)
Short name: TRAF4_MATH
Overlapping homologous superfamilies
- MATH/TRAF domain (IPR002083)
- TNF receptor-associated factor 4, MATH domain (IPR037307)
TNF receptor-associated factor 4 (TRAF4) is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. TRAF4 plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. It regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. TRAF4 modulates TRAF6 functions [PMID: 12023963, PMID: 12801526, PMID: 16052631, PMID: 16157600, PMID: 18953416, PMID: 19937093]. In mouse, it has been shown to be required for normal skeleton development, and for normal development of the respiratory tract [PMID: 10934170]. TRAF4 contains a RING finger domain, seven zinc finger domains, and a TRAF domain.
The TRAF domain can be divided into a more divergent N-terminal alpha helical region (TRAF-N), and a highly conserved C-terminal MATH subdomain (TRAF-C) with an eight-stranded beta-sandwich structure. TRAF-N mediates trimerization while TRAF-C interacts with receptors [PMID: 10206649, PMID: 10518213].
- cd03781 (MATH_TRAF4)