TNF receptor-associated factor 1, MATH domain (IPR037306)
Short name: TRAF1_MATH
Overlapping homologous superfamilies
- MATH/TRAF domain (IPR002083)
- TNF receptor-associated factor 1, MATH domain (IPR037306)
TNF receptor-associated factor 1 (TRAF1) plays a role in the regulation of cell survival and apoptosis [PMID: 10692572]. TRAF1 is unique among TRAF proteins in that it lacks a RING domain found in the N-terminal regions of other TRAFs [PMID: 17633014]. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14 [PMID: 20385093, PMID: 18429822].
TRAF1 is unique among the TRAFs in that it lacks a RING domain, which is critical for the activation of nuclear factor-kappaB and Jun NH2-terminal kinase. Studies on TRAF1-deficient mice suggest that TRAF1 has a negative regulatory role in TNFR-mediated signaling events [PMID: 12023442]. TRAF1 contains one zinc finger and one TRAF domain.
The TRAF domain can be divided into a more divergent N-terminal alpha helical region (TRAF-N), and a highly conserved C-terminal MATH subdomain (TRAF-C) with an eight-stranded beta-sandwich structure. TRAF-N mediates trimerization while TRAF-C interacts with receptors [PMID: 10206649, PMID: 10518213].
- cd03779 (MATH_TRAF1)