TNF receptor-associated factor 1, MATH domain (IPR037306)

Short name: TRAF1_MATH

Overlapping homologous superfamilies


Domain relationships

  • MATH/TRAF domain (IPR002083)
    • TNF receptor-associated factor 1, MATH domain (IPR037306)


TNF receptor-associated factor 1 (TRAF1) plays a role in the regulation of cell survival and apoptosis [PMID: 10692572]. TRAF1 is unique among TRAF proteins in that it lacks a RING domain found in the N-terminal regions of other TRAFs [PMID: 17633014]. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14 [PMID: 20385093, PMID: 18429822].

TRAF1 is unique among the TRAFs in that it lacks a RING domain, which is critical for the activation of nuclear factor-kappaB and Jun NH2-terminal kinase. Studies on TRAF1-deficient mice suggest that TRAF1 has a negative regulatory role in TNFR-mediated signaling events [PMID: 12023442]. TRAF1 contains one zinc finger and one TRAF domain.

The TRAF domain can be divided into a more divergent N-terminal alpha helical region (TRAF-N), and a highly conserved C-terminal MATH subdomain (TRAF-C) with an eight-stranded beta-sandwich structure. TRAF-N mediates trimerization while TRAF-C interacts with receptors [PMID: 10206649, PMID: 10518213].

GO terms

Biological Process

GO:0042981 regulation of apoptotic process

Molecular Function

GO:0005164 tumor necrosis factor receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.