Domain

TRIM37, MATH domain (IPR037299)

Short name: TRIM37_MATH

Domain relationships

Description

This entry represents the MATH (meprin and TRAF homology) domain found in TRIM37, which is a member of the tripartite motif (RING, B-Box, and coiled-coil domains) family and has E3 ubiquitin ligase activity toward itself and histone H2A protein [PMID: 15885686]. TRIM37 localizes to peroxisomes [PMID: 11938494]. Mutations in the human TRIM37 gene (also known as MUL) cause Mulibrey (muscle-liver-brain-eye) nanism, a rare growth disorder of prenatal onset characterized by dysmorphic features, pericardial constriction and hepatomegaly [PMID: 15108285].

TRIM37 contains a tripartite motif and a MATH domain C-terminal to the coiled-coil domain.

GO terms

Biological Process

GO:0016567 protein ubiquitination

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD