Cyclohexadienyl dehydratase pheC (IPR037298)

Short name: PheC_PBP2

Overlapping homologous superfamilies


Domain relationships


This entry represents the periplasmic binding protein type 2 (PBP2) domain found in cyclohexadienyl dehydratase PheC [PMID: 8515238]. Proteins containing this domain catalyze the decarboxylation of prephenate to phenylpyruvate in the alternative phenylalanine biosynthesis pathway in some proteobacteria and archaea [PMID: 1733946]. The PheC proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap [PMID: 11741199]. Since the PheC proteins are so similar to periplasmic binding proteins, (PBP), it is evolutionary plausible that several pre-existing PBP proteins might have been recruited to perform the enzymatic function.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016836 hydro-lyase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.