Homologous Superfamily

Staphostatin A/B (IPR037296)

Short name: Staphostatin_A/B

Overlapping entries


Staphostatin A (SAV1910, SA1726) and B (SspC) are cysteine protease inhibitors belonging to MEROPS inhibitor families I57 and I58 (clan IK). They have a beta-barrel topology that act as specific inhibitors of staphopains, the major secreted cysteine proteases of Staphylococcus aureus [PMID: 15644332, PMID: 14621990]. These inhibitors compete with substrate for binding at the active site of the staphopain, acting to protect intracellular proteins against proteolytic damage by prematurely folded and activated staphopains [PMID: 15716447]. They are also involved in growth capacity, viability and bacterial morphology.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004869 cysteine-type endopeptidase inhibitor activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.