Homologous Superfamily

GDNF receptor alpha (IPR037193)

Short name: GDNF_alpha

Overlapping entries

Description

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons [PMID: 16551639, PMID: 9192899]. GDNF and neurturin promote neuronal survival by signalling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity [PMID: 9192898].

Structurally, GDNF is composed of five helices with an irregular disulfide-linked array. It is topologically similar to the fungal elicitin fold (48646).

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY