Homologous Superfamily

LIS1, N-terminal (IPR037190)

Short name: LIS1_N

Overlapping entries


This entry represents the N-terminal domain of Lissencephaly-1 (LIS1). LIS1 is required for nuclear migration in fungi, cell cycle progression in mammals, and the formation of a folded cerebral cortex in humans. They appear to regulate the mechanical behaviour of cytoplasmic dynein, the primary minus-end-directed microtubule motor [PMID: 22939623]. Proteins containing this domain include:

Mutations in the LIS1 gene cause Lissencephaly-1, a classical lissencephaly characterised by agyria or pachygyria and disorganization of the clear neuronal lamination of normal six-layered cortex [PMID: 9063735].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.