Homologous Superfamily

Staphopain proregion superfamily (IPR037155)

Short name: Staphopain_pro_sf

Overlapping entries


This domain superfamily corresponds to the proregion of the cysteine protease staphopain (MEROPS identifier C47.003). Like many papain type peptidases, staphopain is synthesized as an inactive precursor and cleavage of the proregion is required for activation. This proregion has a half-barrel or barrel-sandwich hybrid fold. The proregion blocks the active site cleft of the mature enzyme on one side of the nucleophilic cysteine [PMID: 15518582].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.