Homologous Superfamily

Colicin/pyocin, DNase domain superfamily (IPR037146)

Short name: Colicin/pyocin_DNase_dom_sf

Overlapping entries



This entry represents the DNase domain found in some colicin/pyocin bacteriocins, including colicin E2, E7, E9 and pyocin S1 and S2. In colicin E7, this domain has been described as a novel alpha/beta fold containing a Zn2+ ion binding site [PMID: 10368275].

Bacteriocins are protein antibiotics that kill bacteria closely related to the producing species. Colicins are a subgroup of bacteriocins that are produced by and target Escherichia coli. The lethal action of most colicins is exerted either by formation of a pore in the cytoplasmic membrane of the target cell, or by an enzymatic nuclease digestion mechanism [PMID: 12423783]. S-type pyocins cause cell death by DNA breakdown due to its endonuclease activity [PMID: 12423794].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004519 endonuclease activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.