Homologous Superfamily

Smad anchor for receptor activation, Smad-binding domain superfamily (IPR037145)

Short name: SARA_Smad-bd_sf

Description

Smad proteins mediate transforming growth factor-beta (TGF-beta) signaling from the transmembrane serine-threonine receptor kinases to the nucleus. SARA (Smad anchor for receptor activation) recruits Smad2 to the TGF-beta receptors for phosphorylation [PMID: 10615055].

This entry represents the Smad-binding domain (SBD) superfamily of SARA. This domain consists of a rigid coil, an alpha helix, and a beta strand, and interacts with Smad2 [PMID: 10615055].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D