Homologous Superfamily

4'-phosphopantetheinyl transferase domain superfamily (IPR037143)

Short name: 4-PPantetheinyl_Trfase_dom_sf

Overlapping entries


The 4'-phosphopantetheinyl transferase domain superfamily of proteins transfer the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of pp-binding. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP [PMID: 7559576]. This superfamily consists of two subtypes: The ACPS type such as ACPS_ECOLI and the Sfp type such as SFP_BACSU. The structure of the Sfp type is known [PMID: 10581256], which shows the active site accommodates a magnesium ion. The most highly conserved regions of the alignment are involved in binding the magnesium ion.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008897 holo-[acyl-carrier-protein] synthase activity
GO:0000287 magnesium ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.