Homologous Superfamily

Rhodopsin, N-terminal domain superfamily (IPR037114)

Short name: Rhodopsin_N_sf

Overlapping entries


Rhodopsin is the archetypal G-protein-coupled receptor. Such receptors participate in virtually all physiological processes as signalling molecules. They utilise heterotrimeric guanosine triphosphate (GTP)-binding proteins to transduce extracellular signals to intracellular events. Rhodopsin is important because of the pivotal role it plays in visual signal transduction. It is a dimeric transmembrane protein whose intradiskal surface consists of an N-terminal domain and three loops connecting six of the seven transmembrane helices. The N-terminal domain is a compact alpha-helical region with breaks and bends at proline residues outside the membrane [PMID: 10888202]. This entry represents the N-terminal domain superfamily, while the transmembrane region is represented by (IPR000276). The N-terminal domain is extracellular is and is necessary for successful dimerisation and molecular stability [PMID: 16567090].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.