Homologous Superfamily

Sporulation initiation phosphotransferase B, C-terminal domain superfamily (IPR037100)

Short name: SpoOB_C_sf


Response regulatory proteins such as sensor kinases control a variety of environmentally induced responses in bacteria. SpoOB is a response regulator that responds to nutritional stress by inducing sporulation. SpoOB is a phosphotransferase that acts upon SpoOA using SpoOF as the phosphor-donor. Phosphorylated SpoOA ca activate sporulation-specific gene transcription [PMID: 1664534].

SpoOB has an alpha-beta core structure that resembles the histidine kinase fold, but lacks the kinase ATP-binding site [PMID: 9809070]. This domain superfamily is found at the C terminus of SpoOB, as well as in other sensor kinases.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.