Homologous Superfamily

Smaug, PHAT domain superfamily (IPR037093)

Short name: PHAT_dom_sf

Overlapping entries


The PHAT (pseudo-HEAT analogous topology) domain assumes a structure consisting of a layer of three parallel helices packed against a layer of two antiparallel helices, into a cylindrical shaped five-helix bundle. It is found in the RNA-binding protein Smaug, where it is essential for high-affinity RNA binding [PMID: 12820967]. Smaug is a translation regulator that binds to the 3'-UTR of specific mRNAs such as nanos (nos) and prevents their translation [PMID: 10606265].

GO terms

Biological Process

GO:0017148 negative regulation of translation

Molecular Function

GO:0003723 RNA binding
GO:0030371 translation repressor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.