Homologous Superfamily

Protein-glutamine gamma-glutamyltransferase superfamily (IPR037084)

Short name: Transglut_prok_sf

Overlapping entries


Protein-glutamine gamma-glutamyltransferase (also known as microbial transglutaminase, MTG) catalyses an acyl transfer reaction by means of a Cys-Asp diad mechanism, in which the gamma-carboxyamide groups of peptide-bound glutamine residues act as the acyl donors. The MTG molecule forms a single, compact domain belonging to the alpha+beta folding class, containing 11 alpha-helices and 8 beta-strands. The alpha-helices and the beta-strands are concentrated mainly at the amino and carboxyl ends of the polypeptide, respectively. These secondary structures are arranged so that a beta-sheet is surrounded by alpha-helices, which are clustered into three regions [PMID: 12221081].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003810 protein-glutamine gamma-glutamyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.