Homologous Superfamily

Formaldehyde-activating enzyme superfamily (IPR037075)

Short name: HCHO-activating_enzyme_sf

Overlapping entries


This superfamily consists of formaldehyde-activating enzyme, or the corresponding domain of longer, bifunctional proteins. It links formaldehyde to the C1 carrier tetrahydromethanopterin (H4MPT), an analog of tetrahydrofolate, and is common among species with H4MPT [PMID: 11073907]. The ribulose monophosphate (RuMP) pathway, which removes the toxic metabolite formaldehyde by assimilation, runs in the opposite direction in some species to produce ribulose 5-phosphate for nucleotide biosynthesis, leaving formaldehyde as an additional metabolite. In these species, formaldehyde activating enzyme may occur as a fusion protein with D-arabino 3-hexulose 6-phosphate formaldehyde lyase from the RuMP pathway.

GO terms

Biological Process

GO:0016051 carbohydrate biosynthetic process

Molecular Function

GO:0016840 carbon-nitrogen lyase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.