Pathways & interactions
Rel homology domain (RHD), DNA-binding domain superfamily (IPR037059)
Short name: RHD_DNA_bind_dom_sf
- NF-kappa-B/Dorsal (IPR000451)
- Nuclear factor of activated T cells (NFAT) (IPR008366)
- p53-like transcription factor, DNA-binding (IPR008967)
- Dorsal-related immunity factor Dif (IPR011363)
- Rel homology domain (RHD), DNA-binding domain (IPR011539)
- Nuclear factor of activated T-cells 1 (IPR015647)
- Transcription factor RelA (p65) (IPR030495)
- Transcription factor RelB (IPR030496)
- Nuclear factor NF-kappa-B, p105 subunit (IPR030503)
- Proto-oncogene c-Rel (IPR030505)
The Rel homology domain (RHD) is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish, NFAT, among others. The RHD is composed of two structural domains: the N-terminal DNA binding domain that is similar to that found in P53, the C-terminal domain has an immunoglobulin-like fold (See PF16179) that functions as a dimerisation domain. This entry represents the N-terminal DNA binding domain superfamily [PMID: 17869269].
Some of these transcription factors appear to form multi-protein DNA-bound complexes [PMID: 9794820]. Phosphorylation of the RHD appears to play a role in the regulation of some of these transcription factors, acting to modulate the expression of their target genes [PMID: 15516339]. The RHD is composed of two immunoglobulin-like beta-barrel subdomains that grip the DNA in the major groove. The N-terminal specificity domain resembles the core domain of the p53 transcription factor, and contains a recognition loop that interacts with DNA bases; the C-terminal dimerisation domain contains the site for interaction with I-kappaB [PMID: 7830764].
- G3DSA:22.214.171.1240 (G3DSA:126.96.36.1990)