Pathways & interactions
L-proline 3-hydroxylase, C-terminal domain superfamily (IPR037037)
Short name: Pro_3_hydrox_C_sf
Iron (II)/2-oxoglutarate (2-OG)-dependent oxygenases catalyse oxidative reactions in a range of metabolic processes. Proline 3-hydroxylase hydroxylates proline at position 3, the first of a 2-OG oxygenase catalysing oxidation of a free alpha-amino acid. The structure contains conserved motifs present in other 2-OG oxygenases including a jelly roll strand core and residues binding iron and 2-oxoglutarate, consistent with divergent evolution within the extended family. The structure differs significantly from many other 2-OG oxygenases in possessing a discrete C-terminal helical domain [PMID: 11737217].
GO:0055114 oxidation-reduction process
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
No terms assigned in this category.
- G3DSA:1.10.1720.10 (G3DSA:1.10.1720.10)